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KMID : 0359920100290050644
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Korean Journal of Nephrology
2010 Volume.29 No. 5 p.644 ~ p.649
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Biopsy-Proven Immune Complex Glomerulonephritis Associated with Sunitinib in a Patient with a Gastrointestinal Stromal Tumor
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Lee Han-Kyu
Lee Hyang-Rim
Oh Kook-Hwan
Moon Kyung-Chul
Ahn Curie
Kim Suhng-Gwon
Bang Young-Jue
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Abstract
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Sunitinib, a multi-targeted tyrosine kinase inhibitor, is used for the treatment of renal cell carcinoma and gastrointestinal stromal tumors. Many adverse effects associated with sunitinib, including hypertension, proteinuria, and thrombotic microangiopathy, have been reported; however, the other forms of glomerulonephritis are very rare. We report a case of biopsy-confirmed immune complex glomerulonephritis in a patient with a gastrointestinal tumor who received sunitinib treatment. The proteinuria subsided partially after sunitinib was discontinued, but when the drug was reintroduced, it recurred.
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KEYWORD
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Glomerulonephritis, Sunitinib, Gastrointestinal stromal tumor
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